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Bis-(2-chlorethyl)-amine HCl

Bis(2-chloroethyl)amine hydrochloride

CAS: 821-48-7

Molecular Formula: C4H9Cl2N·HCl

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Bis-(2-chlorethyl)-amine HCl - Names and Identifiers

Name Bis(2-chloroethyl)amine hydrochloride
Synonyms di(chloroethyl)amino hcl
Bis-(2-chlorethyl)-amine HCl
Bis(2-chloroethyl)ammonium chloride
2-chloro-N-(2-chloroethyl)ethanamine
Bis(2-chloroethyl)amine hydrochloride
Bis-(2-chloroethyl)amine hydrochloride
2-chloro-N-(2-chloroethyl)ethanaminium
2-chloro-N-(2-chloroethyl)ethanaminium chloride
2-Chloro-N-(2-chlorethyl)-ethanamine, Hydrochloride
CAS 821-48-7
EINECS 212-479-5
InChI InChI=1/C4H9Cl2N/c5-1-3-7-4-2-6/h7H,1-4H2/p+1

Bis-(2-chlorethyl)-amine HCl - Physico-chemical Properties

Molecular FormulaC4H9Cl2N·HCl
Molar Mass178.49
Melting Point212-214℃
Boling Point204.2°C at 760 mmHg
Flash Point77.3°C
Water SolubilitySOLUBLE
Vapor Presure0.267mmHg at 25°C
AppearanceMorphological Crystalline Powder
ColorWhite to beige
BRN3550356
Storage ConditionStore below +30°C.
SensitiveHygroscopic
MDLMFCD00012515
UseUsed as a pharmaceutical Intermediate

Bis-(2-chlorethyl)-amine HCl - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs2811
WGK Germany3
RTECSIA1225000
TSCAYes
HS Code29211980
Hazard Class8
Packing GroupIII
ToxicityLD50 orally in Rabbit: 1150 mg/kg

Bis-(2-chlorethyl)-amine HCl - Upstream Downstream Industry

Raw MaterialsDiethanolamine
Downstream Products1-CYCLOPROPYLPIPERAZINE
(4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID
1-AMINO-4-(2-HYDROXYETHYL)PIPERAZINE
N-(3-Trifluoromethylphenyl)piperazine
4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE
3-(4-PHENYL-PIPERAZIN-1-YL)-PROPIONIC ACID
1-(3-NITROPHENYL)-PIPERAZINE
Thiomorpholine
1-(3,5-DICHLOROPHENYL)PIPERAZINE
1-(3-FLUOROPHENYL)PIPERAZINE
1-(1-PHENYLETHYL)PIPERAZINE
1-(4-Methoxyphenyl)piperazine
1-(3-Chlorophenyl)piperazine dihydrochloride
3-(4-methylpiperazin-1-yl)phenylboronic acid
1-(3,4-Dichlorophenyl)piperazine
1-(4-Methoxyphenyl)piperazine dihydrochloride
4-(4-Methylpiperazin-1-yl)phenylboronic Acid
1-[2-(MORPHOLIN-4-YL)-ETHYL]-PIPERAZINE
1-(2-Methoxyphenyl)piperazine hydrobromide
1-(3-METHYLPHENYL)PIPERAZINE
1-(3-Methoxyphenyl)piperazine
1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE
1-(2-ETHOXYPHENYL)PIPERAZINE HYDROCHLORIDE
N-Boc-N,N-bis(2-chloroethyl)amine
1-(4-Chlorophenyl)piperazine
1-(2-Methylphenyl)piperazine
1-(4-METHYLPHENYL)PIPERAZINE
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
N-(2-Methylphenyl)piperazine hydrochloride

Bis-(2-chlorethyl)-amine HCl - Nature

Solubility >100g/l
NIST chemical information 2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA chemical information Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)
Last Update：2024-04-10 22:29:15

Bis-(2-chlorethyl)-amine HCl - Security information

Hazard Note Irritant/Toxic
Last Update：2024-04-10 22:29:15

Bis-(2-chlorethyl)-amine HCl - Uses and synthesis methods

Production method

It is obtained by the reaction of diethanolamine and thionyl chloride. Dissolve thionyl chloride in chloroform, and drop a mixture of diethanolamine and chloroform below 0°C. Control the droplet acceleration to maintain the temperature at -4-6 ℃. After adding, keep the temperature and stir for 30min. Stir at room temperature for 1h, heat to 60-65 ℃, after all crystallization is precipitated, add anhydrous ethanol, heat and reflux to dissolve all. Pour out while hot, cool naturally, and precipitate crystals. Filter the next day and wash twice with chloroform or absolute ethanol. Dry to obtain a finished product with a 76% yield.

category

Toxic substances

Toxicity classification

Highly toxic

Acute toxicity

abdominal cavity-rat LD50: 100 mg/kg; Subcutaneous-mouse LD50: 20 mg/kg

flammability hazard characteristics

Combustible; combustion produces toxic nitrogen oxides, chloride and hydrogen chloride smoke

storage and transportation features

The warehouse is ventilated and dry at low temperature; stored separately from food ingredients

Fire extinguishing agent

Dry powder, foam, sand, carbon dioxide, mist water

Last Update：2024-04-09 20:52:54
Bis-(2-chlorethyl)-amine HCl
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Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Bis(2-chloroethyl)amine hydrochloride Request for quotation
CAS: 821-48-7
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Bis(2-chloroethyl)amine hydrochloride Request for quotation
CAS: 821-48-7
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Trazodone Impurity 14 Visit Supplier Webpage Request for quotation
CAS: 821-48-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Bis(2-chloroethyl)amine hydrochloride Request for quotation
CAS: 821-48-7
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Bis(2-chloroethyl)amine hydrochloride Visit Supplier Webpage Request for quotation
CAS: 821-48-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hangzhou Verychem Science And Technology Co.Ltd
Product Name: Bis(2-chloroethyl)amine hydrochloride Request for quotation
CAS: 821-48-7
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302 Click to send a QQ message
Product List: View Catalog
View History
Bis-(2-chlorethyl)-amine HCl
Raw Materials for Bis-(2-chlorethyl)-amine HCl
Diethanolamine
Downstream Products for Bis-(2-chlorethyl)-amine HCl
1-CYCLOPROPYLPIPERAZINE
N-(3-Trifluoromethylphenyl)piperazine
4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE
3-(4-PHENYL-PIPERAZIN-1-YL)-PROPIONIC ACID
Thiomorpholine
3-(4-methylpiperazin-1-yl)phenylboronic acid
1-(4-Methoxyphenyl)piperazine dihydrochloride
4-(4-Methylpiperazin-1-yl)phenylboronic Acid
1-(3-Methoxyphenyl)piperazine
1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE
1-(2-ETHOXYPHENYL)PIPERAZINE HYDROCHLORIDE
N-Boc-N,N-bis(2-chloroethyl)amine
1-(2-Methylphenyl)piperazine
1-(4-METHYLPHENYL)PIPERAZINE
1-(1-NAPHTHYL)PIPERAZINE HYDROCHLORIDE
N-(2-Methylphenyl)piperazine hydrochloride
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